Product Description: spindle pole body protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005813 | centrosome |
| Component | GO:0000923 | equatorial microtubule organizing center |
| Component | GO:0000930 | gamma-tubulin complex |
| Component | GO:0005634 | nucleus |
| Function | GO:0043015 | gamma-tubulin binding |
| Process | GO:0031122 | cytoplasmic microtubule organization |
| Process | GO:0051321 | meiotic cell cycle |
| Process | GO:0051415 | microtubule nucleation by interphase microtubule organizing center |
| Process | GO:0000278 | mitotic cell cycle |
| Process | GO:0051225 | spindle assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.16 | 0.93 |
| Trophozoite | expressed | 1.18 | 0.43 |
| Schizont | expressed | 0.75 | 0.62 |
| Gametocyte | expressed | 1.43 | 0.34 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0303500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.124 | MFS: -2.943 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0402100)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97225
"Best" AlphaFill ligand hit: UD1 (uridine-diphosphate-n-acetylglucosamine, Local RMSD=0.27) with 6H21 (Global RMSD=22.04)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103557
Most Similar Human Ortholog: H3BS59
TM-align score: 0.88 | RMSD: 1.68
Seq Identity: 0.23 | Length: 102 / 2226
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137822 | tubulin gamma complex associated protein 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 113 | 59 | 123 |
| disruptive | 81 | 264 | 179 | 315 |
| missense | 43 | 206 | 152 | 241 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 32 | 237 | 76 | 153 |
| disruptive | 155 | 595 | 269 | 489 |
| missense | 75 | 450 | 203 | 328 |
PlasmoDB Total SNPs: 232
Non-coding: 32 | Synonymous: 128 | Nonsynonymous: 72 | Stop Codon: 0
Protein Length: 2226 | Molecular Weight (kDa): 267.976
UniProt ID(s): O97225
PDB ID(s): None
Isoelectric Point: 7.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007259 | Gamma-tubulin complex component protein |
| InterPro | IPR040457 | Gamma tubulin complex component, C-terminal |
| InterPro | IPR041470 | Gamma tubulin complex component protein, N-terminal |
| PFam | PF04130 | Gamma tubulin complex component, C-terminal |
| PFam | PF17681 | Gamma tubulin complex component protein, N-terminal |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |