Product Description: plasmoredoxin
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0003756 | protein disulfide isomerase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.03 | 0.99 |
| Trophozoite | no data | 0.12 | 0.92 |
| Schizont | no data | 0.01 | 0.99 |
| Gametocyte | no data | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0303600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.185 | MFS: -3.715 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0402200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0402200)
Modification: Disrupted | RMgm-1837
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I224
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 16 | 5 | 12 |
| disruptive | 1 | 16 | 8 | 29 |
| missense | 1 | 16 | 8 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 20 | 9 | 12 |
| disruptive | 3 | 41 | 19 | 59 |
| missense | 2 | 36 | 11 | 37 |
PlasmoDB Total SNPs: 73
Non-coding: 51 | Synonymous: 18 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 179 | Molecular Weight (kDa): 21.698
Isoelectric Point: 9.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR012336 | Thioredoxin-like fold |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF13905 | Thioredoxin-like fold |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 12631266 | Plasmoredoxin, a novel redox-active protein unique for malarial parasites. | Becker K, Kanzok SM, ..., Rahlfs S | 10.1046/j.1432-1033.2003.03495.x |
| 35434650 | Crystal structure of plasmoredoxin, a redox-active protein unique for malariaparasites | Fritz-Wolf K, Bathke J, Rahlfs S, Becker K | 10.1016/j.crstbi.2022.03.004 |
| 19360125 | Identification of proteins targeted by the thioredoxin superfamily in Plasmodiumfalciparum | Sturm N, Jortzik E, ..., Becker K | 10.1371/journal.ppat.1000383 |