About Gene List

PF3D7_0303900

Genome location: Pf3D7_03_v3:196,570..197,601(-)

Genome classification: Core

Function and Localization

Product Description: phosphatidylethanolamine-binding protein, putative

SignalP Peptide: MFNLKYVVLLWYYLCSVQFIWG

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.00 1.00
Trophozoite not expressed 0.01 0.99
Schizont expressed 0.02 0.99
Gametocyte expressed 0.71 0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0303900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.993 | MFS: -2.694 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLB9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104981

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 15 5 7
disruptive 3 14 13 35
missense 3 14 13 35

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 19 9 15
disruptive 8 39 21 42
missense 6 37 19 37

PlasmoDB Total SNPs: 64

Non-coding: 57 | Synonymous: 4 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 197 | Molecular Weight (kDa): 23.151

UniProt ID(s): Q9NLB9

PDB ID(s): None

Isoelectric Point: 7.01

Protein Domain Annotations:

Source Family ID Description
InterPro IPR005247 YbhB/YbcL
InterPro IPR008914 Phosphatidylethanolamine-binding protein
InterPro IPR036610 PEBP-like superfamily
PFam PF01161 Phosphatidylethanolamine-binding protein
Superfamily SSF49777 PEBP-like superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095