About Gene List

PF3D7_0304100 (IMC1e)

Genome location: Pf3D7_03_v3:203,251..206,328(+)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1e

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0045178 basal part of cell
Component GO:0070258 inner membrane pellicle complex
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed 0.03 0.99
Trophozoite possibly expressed 0.02 0.99
Schizont expressed 0.96 0.64
Gametocyte expressed 1.21 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.858 | MFS: -2.319 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0402700)

Modification: Tagged | RMgm-1121

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97229

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_121438

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 24 16 34
disruptive 21 47 23 44
missense 16 46 22 39

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 45 19 39
disruptive 31 80 44 129
missense 25 68 29 93

PlasmoDB Total SNPs: 171

Non-coding: 121 | Synonymous: 20 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 525 | Molecular Weight (kDa): 61.765

UniProt ID(s): O97229

PDB ID(s): None

Isoelectric Point: 7.09

Protein Domain Annotations:

Source Family ID Description
InterPro IPR022086 Inner membrane complex protein
PFam PF12314 Inner membrane complex protein
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
18359944 Alveolins, a new family of cortical proteins that define the protist infrakingdomAlveolata. Gould SB, Tham WH, ..., Waller RF 10.1093/molbev/msn070
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108