PF3D7_0304300

Genome location: Pf3D7_03_v3:211,970..217,021(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.18	0.91
Trophozoite	not expressed	0.38	0.77
Schizont	not expressed	0.19	0.87
Gametocyte	not expressed	0.39	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.257 | #Insertions: 15

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0402900)

Relative Growth Rate: 0.23 ± 0.15
Confidence: 5.24

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97230

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532932

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	62	39	69
disruptive	40	198	144	264
missense	36	189	137	228

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	126	53	92
disruptive	94	470	213	514
missense	72	383	179	294

PlasmoDB Total SNPs: 171

Non-coding: 32 | Synonymous: 93 | Nonsynonymous: 45 | Stop Codon: 1

Protein Information

Protein Length: 1429 | Molecular Weight (kDa): 172.855

UniProt ID(s): O97230

PDB ID(s): None

Isoelectric Point: 9.46

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095