About Gene List

PF3D7_0304400 (RPL44)

Genome location: Pf3D7_03_v3:217,059..218,992(+)

Genome classification: Core

Function and Localization

Product Description: 60S ribosomal protein L44

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0022625 cytosolic large ribosomal subunit
Component GO:0005634 nucleus
Function GO:0003735 structural constituent of ribosome
Process GO:0006412 translation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte not expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.981 | MFS: -2.234 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97231

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_100788

Most Similar Human Ortholog: Q969Q0

TM-align score: 0.98 | RMSD: 0.41

Seq Identity: 0.66 | Length: 103 / 104

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000165502 ribosomal protein L36a like
ENSG00000241343 ribosomal protein L36a
ENSG00000257529 RPL36A-HNRNPH2 readthrough

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 81

Non-coding: 78 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 104 | Molecular Weight (kDa): 12.157

UniProt ID(s): O97231

PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD

Isoelectric Point: 11.22

Protein Domain Annotations:

Source Family ID Description
InterPro IPR000552 Ribosomal protein L44e
InterPro IPR011332 Zinc-binding ribosomal protein
PFam PF00935 Ribosomal protein L44e
Superfamily SSF57829 Zinc-binding ribosomal protein

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
7941754 RPL44 and RPL44', encoding acidic ribosomal phosphoproteins YP2 alpha(L44) andYP1 beta(L44'), are adjacent to rig and STF1 on Saccharomyces cerevisiaechromosomes XV and IV respectively Rodriguez-Gabriel MA, Zambrano R, Ballesta JP 10.1002/yea.320100515