Product Description: 1-cys-glutaredoxin-like protein-1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.11.1.15 (Transferred entry: 1.11.1.24);1.8.4.2 (Protein-disulfide reductase (glutathione))
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005759 | mitochondrial matrix |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0015036 | disulfide oxidoreductase activity |
| Function | GO:0015038 | glutathione disulfide oxidoreductase activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.19 | 0.88 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.10 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0304500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.418 | MFS: -2.494 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1219700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97232
"Best" AlphaFill ligand hit: GSH (glutathione, Local RMSD=0.12) with 2WUL (Global RMSD=0.71)
BRENDA EC Inhibitors:
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101462
Most Similar Human Ortholog: Q86SX6
TM-align score: 0.68 | RMSD: 2.10
Seq Identity: 0.38 | Length: 116 / 171
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000182512 | glutaredoxin 5 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 8 |
| disruptive | 0 | 6 | 2 | 10 |
| missense | 0 | 6 | 2 | 9 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 5 | 9 |
| disruptive | 1 | 17 | 11 | 33 |
| missense | 1 | 14 | 10 | 24 |
PlasmoDB Total SNPs: 40
Non-coding: 32 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 171 | Molecular Weight (kDa): 19.92
PDB ID(s): None
Isoelectric Point: 9.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002109 | Glutaredoxin |
| InterPro | IPR004480 | Monothiol glutaredoxin-related |
| InterPro | IPR033658 | Glutaredoxin, PICOT-like |
| InterPro | IPR036249 | Thioredoxin-like superfamily |
| PFam | PF00462 | Glutaredoxin |
| Superfamily | SSF52833 | Thioredoxin-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 18452722 | Structural and stability characteristics of a monothiol glutaredoxin:glutaredoxin-like protein 1 from Plasmodium falciparum. | Tripathi T, Rahlfs S, Becker K, Bhakuni V | 10.1016/j.bbapap.2008.03.012 |
| 21203490 | Compartmentation of redox metabolism in malaria parasites. | Kehr S, Sturm N, ..., Becker K | 10.1371/journal.ppat.1001242 |