Product Description: circumsporozoite (CS) protein
SignalP Peptide: MMRKLAILSVSSFLFVEA
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0046658 | anchored component of plasma membrane |
Component | GO:0009986 | cell surface |
Component | GO:0030430 | host cell cytoplasm |
Component | GO:0042025 | host cell nucleus |
Function | GO:0043395 | heparan sulfate proteoglycan binding |
Function | GO:0046812 | host cell surface binding |
Function | GO:0005515 | protein binding |
Process | GO:0044409 | entry into host |
Process | GO:0035891 | exit from host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 0.02 | 0.99 |
Trophozoite | expressed | 0.05 | 0.97 |
Schizont | expressed | 0.01 | 0.99 |
Gametocyte | expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0304600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.962 | MFS: -2.132 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0403200)
Modification: Mutated | RMgm-5235
More info: PhenoPlasm Link
AlphaFill Uniprot ID: M1V0B0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 6 | 8 | 3 | 13 |
disruptive | 44 | 24 | 10 | 31 |
missense | 39 | 16 | 7 | 18 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 8 | 13 | 9 | 18 |
disruptive | 56 | 32 | 20 | 51 |
missense | 44 | 19 | 11 | 31 |
PlasmoDB Total SNPs: 187
Non-coding: 20 | Synonymous: 119 | Nonsynonymous: 48 | Stop Codon: 0
Protein Length: 397 | Molecular Weight (kDa): 42.646
UniProt ID(s): A0A2L1CF52, A0A2L1CF88, C6FGZ3, C6FH27, C6FHG7, M1V060, M1V0A3, M1V0B0, M1V0C4, M1V0E0, M1V9I4, M1VFN9, M1VKZ2, P02893, Q5EIJ9, Q5EIK2, Q5EIK8, Q5EIL3, Q5EIL5, Q5EIL8, Q5R2L2, Q7K740, Q8I9G5, Q8I9J3, Q8I9J4
PDB ID(s): 3VDJ, 3VDK, 3VDL, 6BQB, 6MB3, 6MHG, 7LKB, 7LKG, 7RQQ, 7RQR, 7RXI, 7RXJ, 7RXL, 7RXP, 7S0X, 7UFQ, 8DYT, 8EK1, 8EKA, 8EKF
Isoelectric Point: 5.18
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR000884 | Thrombospondin type-1 (TSP1) repeat |
InterPro | IPR003067 | Plasmodium circumsporozoite protein |
InterPro | IPR036383 | Thrombospondin type-1 (TSP1) repeat superfamily |
PFam | PF00090 | Thrombospondin type-1 (TSP1) repeat |
Superfamily | SSF82895 | Thrombospondin type-1 (TSP1) repeat superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
8006589 | Structural and functional properties of region II-plus of the malariacircumsporozoite protein. | Sinnis P, Clavijo P, ..., Nussenzweig V | 10.1084/jem.180.1.297 |
8478608 | Malaria circumsporozoite protein binds to heparan sulfate proteoglycansassociated with the surface membrane of hepatocytes. | Frevert U, Sinnis P, ..., Nussenzweig V | 10.1084/jem.177.5.1287 |
10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
12244064 | Function of region I and II adhesive motifs of Plasmodium falciparumcircumsporozoite protein in sporozoite motility and infectivity. | Tewari R, Spaccapelo R, ..., Crisanti A | 10.1074/jbc.M208453200 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
15691125 | A survey of the Th2R and Th3R allelic variants in the circumsporozoite proteingene of P. falciparum parasites from western Thailand. | Kumkhaek C, Phra-ek K, ..., Khusmith S | https://pubmed.ncbi.nlm.nih.gov/15691125/ |
16148140 | Are extensive T cell epitope polymorphisms in the Plasmodium falciparumcircumsporozoite antigen, a leading sporozoite vaccine candidate, selected byimmune pressure? | Kumkhaek C, Phra-Ek K, ..., Snounou G | 10.4049/jimmunol.175.6.3935 |
16565072 | Major histocompatibility complex and T cell interactions of a universal T cellepitope from Plasmodium falciparum circumsporozoite protein. | Parra-Lopez C, Calvo-Calle JM, ..., Stern LJ | 10.1074/jbc.M511571200 |
16603573 | Identification and stoichiometry of glycosylphosphatidylinositol-anchoredmembrane proteins of the human malaria parasite Plasmodium falciparum. | Gilson PR, Nebl T, ..., Crabb BS | 10.1074/mcp.M600035-MCP200 |
17597060 | Mosquito heparan sulfate and its potential role in malaria infection andtransmission. | Sinnis P, Coppi A, ..., Linhardt RJ | 10.1074/jbc.M704698200 |
17981117 | Plasmodium circumsporozoite protein promotes the development of the liver stagesof the parasite. | Singh AP, Buscaglia CA, ..., Nussenzweig V | 10.1016/j.cell.2007.09.013 |
19460323 | Natural selection maintains a stable polymorphism at the circumsporozoite proteinlocus of Plasmodium falciparum in a low endemic area. | Putaporntip C, Jongwutiwes S, Hughes AL | 10.1016/j.meegid.2009.02.006 |
19633296 | Structure of the Plasmodium falciparum circumsporozoite protein, a leadingmalaria vaccine candidate. | Plassmeyer ML, Reiter K, ..., Narum DL | 10.1074/jbc.M109.013706 |
22912873 | Genetic variation in the Plasmodium falciparum circumsporozoite protein in Indiaand its relevance to RTS,S malaria vaccine. | Zeeshan M, Alam MT, ..., Sharma YD | 10.1371/journal.pone.0043430 |
23144750 | Protective antibody and CD8+ T-cell responses to the Plasmodium falciparumcircumsporozoite protein induced by a nanoparticle vaccine. | Kaba SA, McCoy ME, ..., Lanar DE | 10.1371/journal.pone.0048304 |
23399449 | A chemiluminescent-western blot assay for quantitative detection of Plasmodiumfalciparum circumsporozoite protein. | Kumar S, Zheng H, ..., Kumar N | 10.1016/j.jim.2013.02.001 |
24983460 | An unstable Th epitope of P. falciparum fosters central memory T cells andanti-CS antibody responses. | Parra-Lopez CA, Bernal-Estevez D, ..., Stern LJ | 10.1371/journal.pone.0100639 |
26169272 | Reversible Conformational Change in the Plasmodium falciparum CircumsporozoiteProtein Masks Its Adhesion Domains. | Herrera R, Anderson C, ..., Narum DL | 10.1128/IAI.02676-14 |
27007512 | Malaria sporozoite protein expression enhances baculovirus-mediated gene transferto hepatocytes. | Tamura T, Kawabata C, ..., Yoshida S | 10.1002/jgm.2879 |
28759593 | Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodiumvivax salivary gland sporozoites. | Swearingen KE, Lindner SE, ..., Mikolajczak SA | https://pubmed.ncbi.nlm.nih.gov/28759593/ |
33600048 | Fluorescent tagging of Plasmodium circumsporozoite protein allows imaging ofsporozoite formation but blocks egress from oocysts. | Singer M, Frischknecht F | 10.1111/cmi.13321 |
33852850 | Avid binding by B cells to the Plasmodium circumsporozoite protein repeatsuppresses responses to protective subdominant epitopes. | Chatterjee D, Lewis FJ, ..., Cockburn IA | 10.1016/j.celrep.2021.108996 |
34507066 | Live attenuated rubella vectors expressing Plasmodium falciparum circumsporozoiteprotein (Pf-CSP) provide a novel malaria vaccine platform in the rhesus macaque. | Virnik K, Zhou W, ..., Berkower I | 10.1016/j.bbrc.2021.08.052 |
36841398 | Genetic variations of Plasmodium falciparum circumsporozoite protein and theimpact on interactions with human immunoproteins and malaria vaccine efficacy. | Dieng CC, Ford CT, ..., Lo E | 10.1016/j.meegid.2023.105418 |