About Gene List

PF3D7_0304700

Genome location: Pf3D7_03_v3:224,160..225,793(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite not expressed 0.08 0.95
Schizont not expressed 0.04 0.98
Gametocyte not expressed 0.14 0.92

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.931 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97233

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533113

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 11 11 22
disruptive 25 64 40 72
missense 21 59 37 58

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 26 17 27
disruptive 54 130 59 109
missense 37 109 50 81

PlasmoDB Total SNPs: 71

Non-coding: 23 | Synonymous: 24 | Nonsynonymous: 24 | Stop Codon: 0

Protein Information

Protein Length: 472 | Molecular Weight (kDa): 56.688

UniProt ID(s): O97233

PDB ID(s): None

Isoelectric Point: 6.4

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095