About Gene List

PF3D7_0304800

Genome location: Pf3D7_03_v3:226,915..231,648(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 6

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.07 0.97
Trophozoite possibly expressed 0.61 0.67
Schizont possibly expressed 0.25 0.86
Gametocyte not expressed 0.57 0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.14 | MFS: -2.945 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97234

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533446

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 62 31 77
disruptive 39 158 111 250
missense 30 129 97 215

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 22 108 56 77
disruptive 113 386 163 404
missense 53 301 133 288

PlasmoDB Total SNPs: 139

Non-coding: 31 | Synonymous: 61 | Nonsynonymous: 47 | Stop Codon: 0

Protein Information

Protein Length: 1446 | Molecular Weight (kDa): 179.224

UniProt ID(s): O97234

PDB ID(s): None

Isoelectric Point: 10.18

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095