PF3D7_0304900

Genome location: Pf3D7_03_v3:231,447..232,745(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.16	0.92
Trophozoite	not expressed	0.15	0.90
Schizont	not expressed	0.05	0.97
Gametocyte	not expressed	0.17	0.89

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0304900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.2 | MFS: -2.864 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0403400)

Relative Growth Rate: 0.22 ± 0.11
Confidence: 5.85

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0403400)

Modification: Disrupted | RMgm-1842

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLB6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_194543

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	8	8	12
disruptive	1	7	6	20
missense	0	7	6	17

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	18	16	11
disruptive	1	23	17	50
missense	0	20	14	30

PlasmoDB Total SNPs: 41

Non-coding: 38 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 170 | Molecular Weight (kDa): 20.838

UniProt ID(s): Q9NLB6

PDB ID(s): None

Isoelectric Point: 7.84

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095