Product Description: elongation factor Ts
SignalP Peptide: MKLFYFFLLSFLSSYIIA
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005759 | mitochondrial matrix |
| Function | GO:0005515 | protein binding |
| Function | GO:0003746 | translation elongation factor activity |
| Process | GO:0070125 | mitochondrial translational elongation |
| Process | GO:0006414 | translational elongation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.18 | 0.91 |
| Trophozoite | expressed | 0.30 | 0.81 |
| Schizont | expressed | 0.22 | 0.85 |
| Gametocyte | expressed | 0.24 | 0.85 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0305000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.154 | MFS: -2.741 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0403500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97235
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101036
Most Similar Human Ortholog: P43897
TM-align score: 0.56 | RMSD: 3.19
Seq Identity: 0.21 | Length: 204 / 390
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000123297 | Ts translation elongation factor, mitochondrial |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 29 | 10 | 19 |
| disruptive | 4 | 33 | 23 | 59 |
| missense | 4 | 32 | 23 | 56 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 45 | 14 | 26 |
| disruptive | 10 | 73 | 50 | 82 |
| missense | 9 | 68 | 43 | 67 |
PlasmoDB Total SNPs: 101
Non-coding: 81 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 2
Protein Length: 390 | Molecular Weight (kDa): 44.897
UniProt ID(s): O97235
PDB ID(s): None
Isoelectric Point: 9.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001816 | Translation elongation factor EFTs/EF1B |
| InterPro | IPR009060 | UBA-like superfamily |
| InterPro | IPR014039 | Translation elongation factor EFTs/EF1B, dimerisation |
| InterPro | IPR036402 | Elongation factor Ts, dimerisation domain superfamily |
| PFam | PF00889 | Translation elongation factor EFTs/EF1B, dimerisation |
| Superfamily | SSF46934 | UBA-like superfamily |
| Superfamily | SSF54713 | Elongation factor Ts, dimerisation domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 21163263 | Interaction of apicoplast-encoded elongation factor (EF) EF-Tu withnuclear-encoded EF-Ts mediates translation in the Plasmodiumfalciparum plastid. | Biswas S, Lim EE, ..., Habib S | 10.1016/j.ijpara.2010.11.003 |
| 25204654 | Kinase-associated endopeptidase 1 (Kae1) participates in an atypicalribosome-associated complex in the apicoplast of Plasmodium falciparum. | Mallari JP, Oksman A, Vaupel B, Goldberg DE | 10.1074/jbc.M114.586735 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |
| 35127825 | Functions and Regulation of Translation Elongation Factors | Xu B, Liu L, Song G | 10.3389/fmolb.2021.816398 |
| 34827164 | Molecular Effects of Elongation Factor Ts and Trigger Factor on the Unfolding and Aggregation of Elongation Factor Tu Induced by the Prokaryotic Molecular Chaperone Hsp33 | Keum M, Ito D, ..., Won HS | 10.3390/biology10111171 |