PF3D7_0305100

Genome location: Pf3D7_03_v3:236,334..248,270(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.24	0.89
Trophozoite	expressed	1.38	0.37
Schizont	possibly expressed	0.68	0.65
Gametocyte	possibly expressed	1.66	0.30

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0305100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.219 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533619

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	59	196	113	239
disruptive	247	824	393	850
missense	129	618	324	684

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	88	387	147	278
disruptive	471	1505	536	1084
missense	242	1134	426	786

PlasmoDB Total SNPs: 543

Non-coding: 0 | Synonymous: 300 | Nonsynonymous: 243 | Stop Codon: 0

Protein Information

Protein Length: 3978 | Molecular Weight (kDa): 475.132

UniProt ID(s): O97236

PDB ID(s): None

Isoelectric Point: 8.71

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095