About Gene List

PF3D7_0305200

Genome location: Pf3D7_03_v3:250,163..255,153(+)

Genome classification: Core

Function and Localization

Product Description: GRIP domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 0.64 0.71
Trophozoite expressed 0.84 0.56
Schizont expressed 1.47 0.36
Gametocyte possibly expressed 0.86 0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0305200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.894 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0403700)

  • Relative Growth Rate: 0.03 ± 0.05
  • Confidence: 7.44

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136973

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 56 26 80
disruptive 26 156 82 201
missense 19 141 74 174

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 31 100 41 81
disruptive 56 322 155 282
missense 37 262 132 204

PlasmoDB Total SNPs: 239

Non-coding: 71 | Synonymous: 107 | Nonsynonymous: 61 | Stop Codon: 0

Protein Information

Protein Length: 1139 | Molecular Weight (kDa): 135.795

UniProt ID(s): D9HMR8, D9HMS8, D9HMS9, D9HMT3, D9HMT9

PDB ID(s): None

Isoelectric Point: 4.63

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108