About Gene List

PF3D7_0305300

Genome location: Pf3D7_03_v3:255,187..259,495(-)

Genome classification: Core

Function and Localization

Product Description: transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 11

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring expressed 1.56 0.36
Trophozoite not expressed 0.76 0.58
Schizont not expressed 0.53 0.67
Gametocyte possibly expressed 0.73 0.60

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0305300

Resistome Missense Mutations: V939E

Resistome Compounds with Missense Mutations: MMV668399

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.973 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97238

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_130909

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 10 45 38 57
disruptive 30 177 71 172
missense 20 139 59 132

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 16 113 38 67
disruptive 91 323 138 319
missense 51 248 102 207

PlasmoDB Total SNPs: 285

Non-coding: 155 | Synonymous: 78 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 956 | Molecular Weight (kDa): 114.503

UniProt ID(s): O97238

PDB ID(s): None

Isoelectric Point: 5.33

Protein Domain Annotations:

Source Family ID Description
InterPro IPR036259 MFS transporter superfamily
InterPro IPR037800 Histone acetyltransferase GCN5
PFam N/A N/A
Superfamily SSF103473 MFS transporter superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095