PF3D7_0305400

Genome location: Pf3D7_03_v3:259,959..261,372(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.04	0.98
Trophozoite	expressed	0.07	0.96
Schizont	possibly expressed	0.06	0.96
Gametocyte	expressed	0.08	0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0305400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.12 | MFS: -2.994 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0403900)

Relative Growth Rate: 0.07 ± 0.11
Confidence: 5.86

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLB5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160722

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	8	14
disruptive	0	6	5	21
missense	0	6	5	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	17	12	17
disruptive	2	21	18	56
missense	2	17	14	28

PlasmoDB Total SNPs: 96

Non-coding: 90 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 145 | Molecular Weight (kDa): 17.517

UniProt ID(s): Q9NLB5

PDB ID(s): None

Isoelectric Point: 10.01

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095