Product Description: protein dopey homolog, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005768 | endosome |
| Component | GO:0016020 | membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005777 | peroxisome |
| Component | GO:0005802 | trans-Golgi network |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.33 | 0.45 |
| Trophozoite | expressed | 1.72 | 0.25 |
| Schizont | expressed | 2.39 | 0.14 |
| Gametocyte | possibly expressed | 1.19 | 0.41 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0305500
Resistome Missense Mutations: D2889N, F3593I
Resistome Compounds with Missense Mutations: AN10248, MMV668399
Resistome # Samples with Disruptive Mutations: 10 (4 missense, 4 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.068 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: N/A
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102162
Most Similar Human Ortholog: Not available
TM-align score: 0.00 | RMSD: 0.00
Seq Identity: 0.00 | Length: / 3933
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000083097 | DOP1 leucine zipper like protein A |
| ENSG00000142197 | DOP1 leucine zipper like protein B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 53 | 210 | 130 | 248 |
| disruptive | 172 | 539 | 275 | 669 |
| missense | 80 | 403 | 206 | 531 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 91 | 426 | 176 | 278 |
| disruptive | 294 | 1126 | 529 | 1093 |
| missense | 146 | 810 | 411 | 694 |
PlasmoDB Total SNPs: 538
Non-coding: 85 | Synonymous: 258 | Nonsynonymous: 195 | Stop Codon: 0
Protein Length: 3933 | Molecular Weight (kDa): 467.882
UniProt ID(s): O97239
PDB ID(s): None
Isoelectric Point: 7.22
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007249 | Dopey, N-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR040314 | Protein dopey |
| PFam | PF04118 | Dopey, N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |