Product Description: ubiquitin-conjugating enzyme MMS2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 6.3.2.19 (Transferred entry: 2.3.2.23, 2.3.2.27 and 6.2.1.45)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0061631 | ubiquitin conjugating enzyme activity |
| Function | GO:0004842 | ubiquitin-protein transferase activity |
| Process | GO:0006301 | postreplication repair |
| Process | GO:0070534 | protein K63-linked ubiquitination |
| Process | GO:0000209 | protein polyubiquitination |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.23 | 0.88 |
| Trophozoite | expressed | 0.50 | 0.70 |
| Schizont | expressed | 0.61 | 0.62 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0305700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.202 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0404200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97241
"Best" AlphaFill ligand hit: NHE (2-[n-cyclohexylamino]ethane sulfonic acid, Local RMSD=0.40) with 4FH1 (Global RMSD=2.22)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 6.3.2.19 | ubiquitin-protein ligase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101344
Most Similar Human Ortholog: G3V2F7
TM-align score: 0.97 | RMSD: 0.53
Seq Identity: 0.46 | Length: 104 / 142
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000124208 | PEDS1-UBE2V1 readthrough |
| ENSG00000244687 | ubiquitin conjugating enzyme E2 V1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 104
Non-coding: 95 | Synonymous: 7 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 142 | Molecular Weight (kDa): 16.14
UniProt ID(s): O97241
Isoelectric Point: 4.61
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000608 | Ubiquitin-conjugating enzyme E2 |
| InterPro | IPR016135 | Ubiquitin-conjugating enzyme/RWD-like |
| PFam | PF00179 | Ubiquitin-conjugating enzyme E2 |
| Superfamily | SSF54495 | Ubiquitin-conjugating enzyme/RWD-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |