Product Description: cytochrome b-c1 complex subunit 8, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 1.00 |
| Trophozoite | expressed | 0.06 | 0.96 |
| Schizont | expressed | 0.07 | 0.94 |
| Gametocyte | expressed | 0.09 | 0.94 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0306000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.91 | MFS: -2.849 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0404400)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q9NLB3
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 6 | 8 |
| disruptive | 1 | 5 | 5 | 16 |
| missense | 1 | 5 | 5 | 14 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 17 | 1 | 5 |
| disruptive | 2 | 16 | 16 | 34 |
| missense | 2 | 13 | 12 | 23 |
PlasmoDB Total SNPs: 70
Non-coding: 66 | Synonymous: 2 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 137 | Molecular Weight (kDa): 17.02
UniProt ID(s): Q9NLB3
PDB ID(s): None
Isoelectric Point: 10.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR036642 | Cytochrome b-c1 complex subunit 8 superfamily |
| PFam | N/A | N/A |
| Superfamily | SSF81508 | Cytochrome b-c1 complex subunit 8 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 33524071 | Divergent features of the coenzyme Q:cytochrome c oxidoreductase complex inToxoplasma gondii parasites. | Hayward JA, Rajendran E, ..., van Dooren GG | 10.1371/journal.ppat.1009211 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 16597436 | Ubiquinone accumulates in the mitochondria of yeast mutated in the ubiquinonebinding protein, Qcr8p | Hagerman RA, Waring NJ, Willis RA, Hagerman AE | 10.2.- |
| 10873857 | Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment | Hunte C, Koepke J, ..., Michel H | 10.1016/s0969-2126(00)00152-0 |
| 8786239 | Subunit 8 of the Saccharomyces cerevisiae cytochrome bc1 complex interacts withsuccinate-ubiquinone reductase complex | Bruel C, Brasseur R, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/8786239/ |
| 9395324 | The role of subunit VIII in the structural stability of the bc1 complex fromSaccharomyces cerevisiae studied using hybrid complexes | Boumans H, Berden JA, Grivell LA | 10.1111/j.1432-1033.1997.t01-3-00762.x |
| 35749136 | Integrated multi-omic data analysis and validation with yeast model showoxidative phosphorylation modulates protein aggregation in amyotrophic lateralsclerosis | Sai Swaroop R, Akhil PS, ..., Sivaramakrishnan V | 10.1080/07391102.2022.2090441 |
| 37094942 | The cytochrome b carboxyl terminal region is necessary for mitochondrial complexIII assembly | Flores-Mireles D, Camacho-Villasana Y, ..., Perez-Martinez X | 10.26508/lsa.202201858 |
| 7748888 | cDNA sequence of subunit VIII of ubiquinol-cytochrome-c oxidoreductase fromSchizosaccharomyces pombe | Boumans H, Berden JA, Grivell LA | 10.1016/0005-2728(95)00035-h |
| 32119834 | Timing of dimerization of the bc(1) complex during mitochondrial respiratorychain assembly | Stephan K, Ott M | 10.1016/j.bbabio.2020.148177 |
| 20832886 | Increased biomass production of industrial bakers' yeasts by overexpression ofHap4 gene | Duenas-Sanchez R, Codon AC, Rincon AM, Benitez T | 10.1016/j.ijfoodmicro.2010.08.009 |
| 11556808 | The N-terminus of the Qcr7 protein of the cytochrome bc(1) complex in S.cerevisiae may be involved in facilitating stability of the subcomplex with theQcr8 protein and cytochrome b | Lee SY, Hunte C, Malaney S, Robinson BH | 10.2.- |
| 8596431 | Distinct transcriptional regulation of a gene coding for a mitochondrial proteinin the yeasts Saccharomyces cerevisiae and Kluyveromyces lactis despite similarpromoter structures | Mulder W, Scholten IH, Grivell LA | 10.1111/j.1365-2958.1995.mmi_17050813.x |
| 36791950 | Delving into the molecular initiating event of cadmium toxification via thedose-dependent functional genomics approach in Saccharomyces cerevisiae | Guan M, Wang X, ..., Zhang X | 10.1016/j.envpol.2023.121287 |
| 11556807 | The functional role of conserved acidic residues of the Qcr7 protein of thecytochrome bc(1) complex in Saccharomyces cerevisiae | Lee SY, Raha S, Nagar B, Robinson BH | 10.2.- |
| 7588747 | Regulation of mitochondrial biogenesis in Saccharomyces cerevisiae. Intricateinterplay between general and specific transcription factors in the promoter ofthe QCR8 gene | De Winde JH, Grivell LA | 10.1111/j.1432-1033.1995.200_1.x |
| 9003361 | Subunit VII of ubiquinol:cytochrome-c oxidoreductase from Neurospora crassa isfunctional in yeast and has an N-terminal extension that is not essential formitochondrial targeting | Lobo-Hajdu G, Braun HP, ..., Schmitz UK | 10.1042/bj3200769 |