About Gene List

PF3D7_0306100

Genome location: Pf3D7_03_v3:287,946..291,323(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.40 0.80
Trophozoite not expressed 0.57 0.67
Schizont not expressed 0.22 0.86
Gametocyte not expressed 0.42 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0306100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -2.924 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97243

"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=23.65) with 6MT9 (Global RMSD=31.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533174

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 30 21 44
disruptive 25 110 50 133
missense 20 97 47 115

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 75 21 46
disruptive 55 235 97 187
missense 41 196 89 131

PlasmoDB Total SNPs: 156

Non-coding: 102 | Synonymous: 22 | Nonsynonymous: 32 | Stop Codon: 0

Protein Information

Protein Length: 628 | Molecular Weight (kDa): 74.327

UniProt ID(s): O97243

PDB ID(s): None

Isoelectric Point: 4.46

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104