Product Description: FAD-dependent glycerol-3-phosphate dehydrogenase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: 1.1.5.3 (Glycerol-3-phosphate dehydrogenase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004368 | glycerol-3-phosphate dehydrogenase (quinone) activity |
| Process | GO:0006127 | glycerophosphate shuttle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.16 | 0.89 |
| Schizont | expressed | 0.17 | 0.88 |
| Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0306400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.988 | MFS: -2.349 | #Insertions: 1
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0404800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0404800)
Modification: Disrupted | RMgm-1852
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97245
"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.57) with 3DA1 (Global RMSD=2.91)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.1.5.3 | glycerol-3-phosphate dehydrogenase | FMNNEMPCMBDTNBK3PO4SeconalmethanolacetamidecisplatinDigitoninAl2(SO4)3adriamycin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101157
Most Similar Human Ortholog: F5GYK7
TM-align score: 0.87 | RMSD: 2.63
Seq Identity: 0.43 | Length: 354 / 653
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000115159 | glycerol-3-phosphate dehydrogenase 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 42 | 14 | 38 |
| disruptive | 6 | 26 | 15 | 37 |
| missense | 4 | 26 | 14 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 18 | 73 | 27 | 53 |
| disruptive | 7 | 62 | 40 | 127 |
| missense | 5 | 57 | 30 | 81 |
PlasmoDB Total SNPs: 142
Non-coding: 132 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 653 | Molecular Weight (kDa): 74.688
UniProt ID(s): O97245
PDB ID(s): None
Isoelectric Point: 8.66
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000447 | FAD-dependent glycerol-3-phosphate dehydrogenase |
| InterPro | IPR006076 | FAD dependent oxidoreductase |
| InterPro | IPR031656 | Alpha-glycerophosphate oxidase, C-terminal |
| InterPro | IPR036188 | FAD/NAD(P)-binding domain superfamily |
| PFam | PF01266 | FAD dependent oxidoreductase |
| PFam | PF16901 | Alpha-glycerophosphate oxidase, C-terminal |
| Superfamily | SSF51905 | FAD/NAD(P)-binding domain superfamily |
| Superfamily | SSF54373 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |