Product Description: cytochrome c oxidase subunit 6c, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005751 | mitochondrial respiratory chain complex IV |
| Component | GO:0005739 | mitochondrion |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.20 | 0.87 |
| Schizont | expressed | 0.16 | 0.88 |
| Gametocyte | expressed | 0.36 | 0.78 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0306500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.174 | MFS: -2.693 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0404900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97246
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 7 | 26 |
| disruptive | 3 | 28 | 8 | 35 |
| missense | 3 | 27 | 8 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 43 | 10 | 20 |
| disruptive | 9 | 51 | 27 | 56 |
| missense | 8 | 44 | 25 | 31 |
PlasmoDB Total SNPs: 85
Non-coding: 67 | Synonymous: 14 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 299 | Molecular Weight (kDa): 36.391
UniProt ID(s): O97246
PDB ID(s): None
Isoelectric Point: 9.79
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 30204084 | Elucidating the mitochondrial proteome of Toxoplasma gondii reveals the presenceof a divergent cytochrome c oxidase | Seidi A, Muellner-Wong LS, ..., van Dooren GG | 10.7554/eLife.38131 |
| 34155201 | Composition and stage dynamics of mitochondrial complexes in Plasmodiumfalciparum. | Evers F, Cabrera-Orefice A, ..., Kooij TWA | 10.1038/s41467-021-23919-x |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38096616 | NDUFA8 is transcriptionally regulated by EP300/H3K27ac and promotes mitochondrialrespiration to support proliferation and inhibit apoptosis in cervical cancer | Xiang H, Tang H, ..., Wang Y | 10.1016/j.bbrc.2023.149374 |
| 35879322 | Novel role of COX6c in the regulation of oxidative phosphorylation and diseases | Wang C, Lv J, ..., Zhang S | 10.1038/s41420-022-01130-1 |