PF3D7_0306700 (EMC5)

Genome location: Pf3D7_03_v3:303,434..305,619(+)

Genome classification: Core

Function and Localization

Product Description: ER membrane protein complex subunit 5, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0072546	EMC complex
Process	GO:0034975	protein folding in endoplasmic reticulum

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.35	0.83
Trophozoite	expressed	0.65	0.62
Schizont	expressed	0.14	0.91
Gametocyte	expressed	0.49	0.72

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0306700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.449 | MFS: -3.391 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0405100)

Relative Growth Rate: 0.15 ± 0.09
Confidence: 6.26

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLB0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532677

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 97

Non-coding: 89 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 3

Protein Information

Protein Length: 116 | Molecular Weight (kDa): 13.267

UniProt ID(s): Q9NLB0

PDB ID(s): None

Isoelectric Point: 8.73

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095