Product Description: T-complex protein 1 subunit beta
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005832 | chaperonin-containing T-complex |
| Component | GO:0005829 | cytosol |
| Component | GO:0005634 | nucleus |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.89 | 0.62 |
| Trophozoite | expressed | 1.37 | 0.38 |
| Schizont | expressed | 0.15 | 0.91 |
| Gametocyte | expressed | 0.73 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0306800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.191 | MFS: -2.7 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0405200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97247
"Best" AlphaFill ligand hit: ANP (phosphoaminophosphonic acid-adenylate ester, Local RMSD=0.74) with 1Q3Q (Global RMSD=2.16)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101721
Most Similar Human Ortholog: P78371
TM-align score: 0.98 | RMSD: 1.20
Seq Identity: 0.57 | Length: 528 / 533
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000166226 | chaperonin containing TCP1 subunit 2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 21 | 24 | 33 |
| disruptive | 2 | 9 | 9 | 35 |
| missense | 2 | 8 | 9 | 34 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 10 | 69 | 18 | 32 |
| disruptive | 3 | 28 | 17 | 84 |
| missense | 2 | 25 | 15 | 66 |
PlasmoDB Total SNPs: 105
Non-coding: 85 | Synonymous: 15 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 533 | Molecular Weight (kDa): 59.199
UniProt ID(s): O97247
PDB ID(s): None
Isoelectric Point: 5.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002194 | Chaperonin TCP-1, conserved site |
| InterPro | IPR002423 | Chaperonin Cpn60/TCP-1 family |
| InterPro | IPR012716 | T-complex protein 1, beta subunit |
| InterPro | IPR017998 | Chaperone tailless complex polypeptide 1 (TCP-1) |
| InterPro | IPR027409 | GroEL-like apical domain superfamily |
| InterPro | IPR027410 | TCP-1-like chaperonin intermediate domain superfamily |
| InterPro | IPR027413 | GroEL-like equatorial domain superfamily |
| PFam | PF00118 | Chaperonin Cpn60/TCP-1 family |
| Superfamily | SSF48592 | GroEL-like equatorial domain superfamily |
| Superfamily | SSF52029 | GroEL-like apical domain superfamily |
| Superfamily | SSF54849 | TCP-1-like chaperonin intermediate domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25615740 | New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of theParasite Group II Chaperonin, PfTRiC. | Mbengue A, Vialla E, ..., Braun-Breton C | 10.1111/tra.12266 |
| 28067475 | The chaperonin T RiC forms an oligomeric complex in the malaria parasite cytosol | Spillman NJ, Beck JR, ..., Goldberg DE | 10.1111/cmi.12719 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 37730860 | Author Correction: Reduced ADP off-rate by the yeast CCT2 double mutationT394P/R510H which causes Leber congenital amaurosis in humans | Roy M, Fleisher RC, Alexandrov AI, Horovitz A | 10.1038/s42003-023-05357-1 |
| 37644231 | Reduced ADP off-rate by the yeast CCT2 double mutation T394P/R510H which causesLeber congenital amaurosis in humans | Roy M, Fleisher RC, Alexandrov AI, Horovitz A | 10.1038/s42003-023-05261-8 |