Product Description: 40S ribosomal protein S23, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022627 | cytosolic small ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Component | GO:0005840 | ribosome |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.94 | 0.29 |
| Trophozoite | expressed | 2.26 | 0.16 |
| Schizont | expressed | 0.49 | 0.72 |
| Gametocyte | expressed | 1.28 | 0.41 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0306900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.139 | MFS: -2.925 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0405300)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97248
"Best" AlphaFill ligand hit: AM2 (4-o-(3alpha-amino-6alpha-((4-amino-4-deoxy-alpha-d-glucopyranosyl)oxy)-2,3,4,5abeta,6,7,8,8aalpha-octahydro-8beta-hydroxy-7beta-(methylamino)pyrano(3,2-b)pyran-2alpha-yl)-2-deoxy-d-streptamine, Local RMSD=0.08) with 4AQY (Global RMSD=4.60)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100935
Most Similar Human Ortholog: P62266
TM-align score: 0.99 | RMSD: 0.43
Seq Identity: 0.78 | Length: 143 / 145
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000186468 | ribosomal protein S23 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 198
Non-coding: 193 | Synonymous: 4 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 145 | Molecular Weight (kDa): 16.13
UniProt ID(s): O97248
PDB ID(s): 3J7A, 3JBN, 3JBO, 3JBP
Isoelectric Point: 11.51
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005680 | Ribosomal protein S23, eukaryotic/archaeal |
| InterPro | IPR006032 | Ribosomal protein S12/S23 |
| InterPro | IPR012340 | Nucleic acid-binding, OB-fold |
| PFam | PF00164 | Ribosomal protein S12/S23 |
| Superfamily | SSF50249 | Nucleic acid-binding, OB-fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |