Product Description: 60S ribosomal protein L7, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.42 | 0.41 |
| Trophozoite | expressed | 1.40 | 0.36 |
| Schizont | expressed | 0.26 | 0.83 |
| Gametocyte | expressed | 0.89 | 0.55 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0307200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -3.165 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97250
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100755
Most Similar Human Ortholog: A8MUD9
TM-align score: 0.99 | RMSD: 0.49
Seq Identity: 0.48 | Length: 208 / 257
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000147604 | ribosomal protein L7 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 10 | 13 | 13 |
| disruptive | 2 | 6 | 7 | 32 |
| missense | 2 | 6 | 7 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 27 | 15 | 18 |
| disruptive | 2 | 27 | 26 | 62 |
| missense | 2 | 21 | 21 | 43 |
PlasmoDB Total SNPs: 95
Non-coding: 92 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 257 | Molecular Weight (kDa): 30.523
UniProt ID(s): O97250
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.01
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005998 | Ribosomal protein L7, eukaryotic |
| InterPro | IPR012988 | Ribosomal protein L30, N-terminal |
| InterPro | IPR016082 | Ribosomal protein L30, ferredoxin-like fold domain |
| InterPro | IPR035808 | Ribosomal protein L7, eukaryotic/archaeal |
| InterPro | IPR036919 | Ribosomal protein L30, ferredoxin-like fold domain superfamily |
| InterPro | IPR039699 | Ribosomal protein L7/L30 |
| PFam | PF00327 | Ribosomal protein L30, ferredoxin-like fold domain |
| PFam | PF08079 | Ribosomal protein L30, N-terminal |
| Superfamily | SSF55129 | Ribosomal protein L30, ferredoxin-like fold domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |