Product Description: spindle and kinetochore-associated protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000776 | kinetochore |
| Component | GO:0005634 | nucleus |
| Component | GO:0000940 | outer kinetochore |
| Component | GO:0005876 | spindle microtubule |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0007059 | chromosome segregation |
| Process | GO:0000278 | mitotic cell cycle |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.36 | 0.77 |
| Schizont | expressed | 0.21 | 0.86 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0307500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -2.971 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0405800)
Modification: Tagged | RMgm-5110
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O97253
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 7 | 18 | 13 | 16 |
| disruptive | 24 | 50 | 20 | 40 |
| missense | 15 | 23 | 11 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 33 | 16 | 18 |
| disruptive | 41 | 75 | 38 | 74 |
| missense | 20 | 37 | 28 | 41 |
PlasmoDB Total SNPs: 181
Non-coding: 111 | Synonymous: 31 | Nonsynonymous: 38 | Stop Codon: 1
Protein Length: 389 | Molecular Weight (kDa): 46.329
PDB ID(s): None
Isoelectric Point: 9.53
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR026762 | Spindle and kinetochore-associated protein 2 |
| InterPro | IPR042091 | Ska2, N-terminal |
| PFam | PF11362 | Ska2, N-terminal |
| PFam | PF16740 | |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 36006241 | Composition and organization of kinetochores show plasticity in apicomplexanchromosome segregation | Brusini L, Dos Santos Pacheco N, ..., Brochet M | 10.1083/jcb.202111084 |