About Gene List

PF3D7_0307600

Genome location: Pf3D7_03_v3:325,654..328,649(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.09 0.96
Trophozoite expressed 0.77 0.58
Schizont expressed 0.49 0.71
Gametocyte expressed 0.87 0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0307600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.923 | MFS: -1.227 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0405900)

  • Relative Growth Rate: 0.91 ± 0.13
  • Confidence: 5.50

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0405900)

Modification: Disrupted | RMgm-1860

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97254

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533448

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 42 27 62
disruptive 32 112 70 134
missense 26 104 65 118

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 13 86 31 56
disruptive 52 241 108 192
missense 37 210 95 123

PlasmoDB Total SNPs: 130

Non-coding: 51 | Synonymous: 41 | Nonsynonymous: 38 | Stop Codon: 0

Protein Information

Protein Length: 746 | Molecular Weight (kDa): 88.219

UniProt ID(s): O97254

PDB ID(s): None

Isoelectric Point: 9.36

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104