About Gene List

PF3D7_0307800

Genome location: Pf3D7_03_v3:336,191..339,907(+)

Genome classification: Core

Function and Localization

Product Description: PDZ domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.17 0.92
Trophozoite possibly expressed 0.67 0.63
Schizont possibly expressed 0.31 0.80
Gametocyte possibly expressed 0.24 0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0307800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -2.753 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77318

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533013

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 38 21 25
disruptive 13 47 29 88
missense 9 43 27 80

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 70 24 35
disruptive 22 109 65 149
missense 10 93 54 101

PlasmoDB Total SNPs: 179

Non-coding: 102 | Synonymous: 44 | Nonsynonymous: 33 | Stop Codon: 0

Protein Information

Protein Length: 699 | Molecular Weight (kDa): 81.678

UniProt ID(s): O77318, Q95V41

PDB ID(s): None

Isoelectric Point: 6.07

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001478 PDZ domain
InterPro IPR036034 PDZ superfamily
PFam PF00595 PDZ domain
Superfamily SSF50156 PDZ superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895