PF3D7_0307900

Genome location: Pf3D7_03_v3:339,591..352,137(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.15	0.93
Trophozoite	possibly expressed	0.72	0.64
Schizont	not expressed	0.12	0.93
Gametocyte	not expressed	1.35	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0307900

Resistome Missense Mutations: L2968F

Resistome Compounds with Missense Mutations: GNF-Pf-3600

Resistome # Samples with Disruptive Mutations: 7 (6 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.196 | #Insertions: 24

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0406200)

Modification: Disrupted | RMgm-4209

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_122786

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	159	102	184
disruptive	254	625	292	653
missense	160	486	252	527

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	58	278	126	215
disruptive	406	1043	435	829
missense	242	814	368	624

PlasmoDB Total SNPs: 771

Non-coding: 202 | Synonymous: 244 | Nonsynonymous: 325 | Stop Codon: 0

Protein Information

Protein Length: 3724 | Molecular Weight (kDa): 448.207

UniProt ID(s): O77320

PDB ID(s): None

Isoelectric Point: 6.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095