Product Description: DNA polymerase delta small subunit, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.7.7 (DNA-directed DNA polymerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0042575 | DNA polymerase complex |
| Component | GO:0043625 | delta DNA polymerase complex |
| Function | GO:0003887 | DNA-directed DNA polymerase activity |
| Process | GO:0071897 | DNA biosynthetic process |
| Process | GO:0006271 | DNA strand elongation involved in DNA replication |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.07 | 0.97 |
| Trophozoite | expressed | 0.53 | 0.69 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | expressed | 0.39 | 0.77 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0308000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.834 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_0408600)
Modification: Tagged | RMgm-4980
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77321
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.7.7 | DNA-directed DNA polymerase | KClEDTANH4+dATPNH4ClddTTPMK886UracilalliinsucroseethanolAllicin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102286
Most Similar Human Ortholog: P49005
TM-align score: 0.84 | RMSD: 2.46
Seq Identity: 0.31 | Length: 417 / 498
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000106628 | DNA polymerase delta 2, accessory subunit |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 16 | 13 | 29 |
| disruptive | 20 | 32 | 17 | 59 |
| missense | 2 | 23 | 11 | 53 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 43 | 24 | 29 |
| disruptive | 34 | 78 | 38 | 64 |
| missense | 6 | 57 | 28 | 48 |
PlasmoDB Total SNPs: 245
Non-coding: 183 | Synonymous: 26 | Nonsynonymous: 35 | Stop Codon: 1
Protein Length: 498 | Molecular Weight (kDa): 57.722
UniProt ID(s): O77321
PDB ID(s): None
Isoelectric Point: 5.48
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007185 | DNA polymerase alpha/delta/epsilon, subunit B |
| InterPro | IPR024826 | DNA polymerase delta/II small subunit family |
| InterPro | IPR040663 | DNA polymerase delta subunit, OB-fold domain |
| InterPro | IPR041863 | DNA polymerase delta subunit 2, C-terminal domain |
| PFam | PF04042 | DNA polymerase alpha/delta/epsilon, subunit B |
| PFam | PF18018 | DNA polymerase delta subunit, OB-fold domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |