About Gene List

PF3D7_0308300 (PIC4)

Genome location: Pf3D7_03_v3:365,177..366,948(-)

Genome classification: Core

Function and Localization

Product Description: PhIL1-interacting candidate PIC4

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0009986 cell surface
Component GO:0070258 inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.16 0.93
Trophozoite not expressed 0.04 0.98
Schizont expressed 0.70 0.71
Gametocyte not expressed 0.07 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0308300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -2.985 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77324

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532669

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 22 15 30
disruptive 10 37 18 55
missense 10 37 17 46

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 50 12 16
disruptive 22 84 45 100
missense 18 74 39 57

PlasmoDB Total SNPs: 91

Non-coding: 71 | Synonymous: 7 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 337 | Molecular Weight (kDa): 38.944

UniProt ID(s): O77324

PDB ID(s): None

Isoelectric Point: 4.97

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
20037583 Transcriptional profiling of growth perturbations of the human malaria parasitePlasmodium falciparum. Hu G, Cabrera A, ..., Bozdech Z 10.1038/nbt.1597
33830607 Identification of novel inner membrane complex and apical annuli proteins of themalaria parasite Plasmodium falciparum. Wichers JS, Wunderlich J, ..., Gilberger TW 10.1111/cmi.13341