About Gene List

PF3D7_0308500

Genome location: Pf3D7_03_v3:369,925..371,806(+)

Genome classification: Core

Function and Localization

Product Description: activator of Hsp90 ATPase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.49 0.77
Trophozoite expressed 1.11 0.47
Schizont expressed 0.21 0.87
Gametocyte expressed 0.38 0.78

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0308500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.46 | MFS: -2.208 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0406700)

  • Relative Growth Rate: 0.87 ± 0.10
  • Confidence: 6.08

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0406700)

Modification: Disrupted | RMgm-1864

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O97256

"Best" AlphaFill ligand hit: KAI (kainate, Local RMSD=3.57) with 3EN3 (Global RMSD=14.82)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102661

Most Similar Human Ortholog: G3V438

TM-align score: 0.88 | RMSD: 1.28

Seq Identity: 0.30 | Length: 130 / 140

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100591 activator of HSP90 ATPase activity 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 11 6 6
disruptive 0 6 6 21
missense 0 6 6 21

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 3 21 0 12
disruptive 2 25 24 38
missense 2 21 21 21

PlasmoDB Total SNPs: 162

Non-coding: 155 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 1

Protein Information

Protein Length: 140 | Molecular Weight (kDa): 16.156

UniProt ID(s): O97256, Q689C4

PDB ID(s): None

Isoelectric Point: 7.32

Protein Domain Annotations:

Source Family ID Description
InterPro IPR013538 Activator of Hsp90 ATPase homologue 1-like
InterPro IPR039981 Activator of 90kDa heat shock protein ATPase-like
PFam PF08327 Activator of Hsp90 ATPase homologue 1-like
Superfamily SSF55961 N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108