About Gene List

PF3D7_0309100 (OMD)

Genome location: Pf3D7_03_v3:386,977..388,538(-)

Genome classification: Core

Function and Localization

Product Description: OMD protein, putative

SignalP Peptide: MNMIMKIYYIFLLFVFILIERCVDN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Process GO:0071976 cell gliding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.01 1.00
Trophozoite expressed 0.01 1.00
Schizont expressed 0.01 0.99
Gametocyte expressed 0.27 0.85

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0309100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 1 | MFS: 0 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0407300)

  • Relative Growth Rate: 1.06 ± 0.13
  • Confidence: 5.40

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_0407300)

Modification: Tagged | RMgm-4689

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLA8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532545

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 9 9 17
disruptive 4 10 4 17
missense 4 10 3 17

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 21 15 16
disruptive 6 25 10 42
missense 5 23 7 34

PlasmoDB Total SNPs: 137

Non-coding: 119 | Synonymous: 15 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 178 | Molecular Weight (kDa): 21.433

UniProt ID(s): Q9NLA8

PDB ID(s): None

Isoelectric Point: 4.38

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
31553751 Malaria transmission through the mosquito requires the function of the OMDprotein. Curra C, Kehrer J, ..., Mair GR 10.1371/journal.pone.0222226