Product Description: 60S acidic ribosomal protein P2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0009986 | cell surface |
| Component | GO:0044228 | host cell surface |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0044409 | entry into host |
| Process | GO:0051262 | protein tetramerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 2.62 | 0.13 |
| Trophozoite | expressed | 2.93 | 0.07 |
| Schizont | expressed | 1.07 | 0.49 |
| Gametocyte | expressed | 2.12 | 0.15 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0309600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.132 | MFS: -3.225 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0407700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O00806
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100883
Most Similar Human Ortholog: P05387
TM-align score: 0.57 | RMSD: 2.35
Seq Identity: 0.43 | Length: 74 / 112
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000177600 | ribosomal protein lateral stalk subunit P2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 123
Non-coding: 121 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22912579 | Arrest of nuclear division in Plasmodium through blockage of erythrocyte surfaceexposed ribosomal protein P2. | Das S, Basu H, ..., Sharma S | 10.1371/journal.ppat.1002858 |
| 23060439 | Erythrocytic stage-dependent regulation of oligomerization of Plasmodiumribosomal protein P2. | Das S, Sudarsan R, Sivakami S, Sharma S | 10.1074/jbc.M112.384388 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25280460 | Ribosomal protein P2 localizes to the parasite zoite-surface and is a target forinvasion inhibitory antibodies in Toxoplasma gondii and Plasmodium falciparum. | Sudarsan R, Chopra RK, Khan MA, Sharma S | 10.1016/j.parint.2014.08.006 |
| 25412900 | The C-terminal domain of eukaryotic acidic ribosomal P2 proteins is intrinsicallydisordered with conserved structural propensities. | Mishra P, Rajagopal S, Sharma S, Hosur RV | 10.2174/0929866521666141121160523 |
| 25450178 | In vivo formation of Plasmodium falciparum ribosomal stalk - a unique mode ofassembly without stable heterodimeric intermediates. | Wawiorka L, Krokowski D, ..., Tchorzewski M | 10.1016/j.bbagen.2014.10.015 |
| 29124138 | Molten globule nature of Plasmodium falciparum P2 homo-tetramer. | Mishra P, Choudhary S, ..., Hosur RV | 10.1016/j.bbrep.2015.03.010 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 32717409 | Molecular study of binding of Plasmodium ribosomal protein P2 to erythrocytes. | Mishra P, Dmello C, ..., Sharma S | 10.1016/j.biochi.2020.07.007 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 23581826 | Residue level description of in vivo self-association of Plasmodium falciparumP2 | Mishra P, Sharma S, Hosur RV | 10.1080/07391102.2013.782827 |