Product Description: SECIS-binding protein 2, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003730 | mRNA 3'-UTR binding |
| Function | GO:0043021 | ribonucleoprotein complex binding |
| Function | GO:0035368 | selenocysteine insertion sequence binding |
| Process | GO:0001514 | selenocysteine incorporation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.36 | 0.82 |
| Trophozoite | not expressed | 0.40 | 0.78 |
| Schizont | not expressed | 0.16 | 0.90 |
| Gametocyte | not expressed | 0.95 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0309700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.173 | #Insertions: 3
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0407800)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0407800)
Modification: Disrupted | RMgm-1874
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77331
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105656
Most Similar Human Ortholog: Q93073
TM-align score: 0.29 | RMSD: 5.23
Seq Identity: 0.18 | Length: 216 / 608
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000138593 | SECIS binding protein 2 like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 37 | 19 | 46 |
| disruptive | 22 | 112 | 52 | 128 |
| missense | 12 | 89 | 43 | 92 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 70 | 31 | 50 |
| disruptive | 56 | 251 | 81 | 217 |
| missense | 25 | 183 | 52 | 139 |
PlasmoDB Total SNPs: 102
Non-coding: 0 | Synonymous: 78 | Nonsynonymous: 24 | Stop Codon: 0
Protein Length: 608 | Molecular Weight (kDa): 71.463
UniProt ID(s): O77331
PDB ID(s): None
Isoelectric Point: 10.65
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004038 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| InterPro | IPR029064 | 50S ribosomal protein L30e-like |
| InterPro | IPR040051 | Selenocysteine insertion sequence-binding protein 2 |
| PFam | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| Superfamily | SSF55315 | 50S ribosomal protein L30e-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |