Product Description: YTH domain-containing protein 2
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Function | GO:1990247 | N6-methyladenosine-containing RNA binding |
| Function | GO:0003729 | mRNA binding |
| Process | GO:0061157 | mRNA destabilization |
| Process | GO:0006417 | regulation of translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.02 | 0.98 |
| Schizont | possibly expressed | 0.01 | 0.99 |
| Gametocyte | possibly expressed | 0.06 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0309800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.281 | MFS: -2.656 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0407900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77335
"Best" AlphaFill ligand hit: TOE (2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxyl, Local RMSD=0.13) with 7NJC (Global RMSD=2.44)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9Y5A9 | YTH domain-containing family protein 2 | OrthoMCL BLAST | US20230322715, Compound TR-YTH-01US20230322715, Compound TR-YTH-02US20230322715, Compound TR-YTH-03US20230322715, Compound TR-YTH-04... | |
| Q9BYJ9 | YTH domain-containing family protein 1 | OrthoMCL BLAST | US20230322715, Compound TR-YTH-01US20230322715, Compound TR-YTH-02US20230322715, Compound TR-YTH-03US20230322715, Compound TR-YTH-04... |
Ortholog Group (OrthoMCL): OG6_105604
Most Similar Human Ortholog: Q96MU7
TM-align score: 0.54 | RMSD: 3.51
Seq Identity: 0.34 | Length: 171 / 280
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000083896 | YTH domain containing 1 |
| ENSG00000275272 | YTH domain containing 1 |
Protein Length: 280 | Molecular Weight (kDa): 33.09
UniProt ID(s): O77335
PDB ID(s): None
Isoelectric Point: 7.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007275 | YTH domain |
| PFam | PF04146 | YTH domain |
| Superfamily | N/A | N/A |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 10 | 11 | 25 |
| disruptive | 2 | 12 | 14 | 33 |
| missense | 2 | 10 | 12 | 31 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 32 | 17 | 25 |
| disruptive | 7 | 36 | 31 | 80 |
| missense | 3 | 29 | 24 | 60 |
PlasmoDB Total SNPs: 130
Non-coding: 112 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 3
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 32867812 | N(6)-Adenosine methylation on mRNA is recognized by YTH2 domain protein of humanmalaria parasite Plasmodium falciparum. | Govindaraju G, Kadumuri RV, ..., Rajavelu A | 10.1186/s13072-020-00355-7 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |
| 38316392 | Reading the epitranscriptome of the human malaria parasite | Govindaraju G, Rajavelu A | 10.1016/j.bj.2024.100703 |
| 34809465 | Plasmodium falciparum YTH2 Domain Binds to m6A-Containing mRNA and RegulatesTranslation | Govindaraju G, Chavali S, Rajavelu A | 10.1128/mBio.01367-21 |
| 32962747 | Correction to: N(6)_Adenosine methylation on mRNA is recognized by YTH2 domain protein of human malaria parasite Plasmodium falciparum | Govindaraju G, Kadumuri RV, ..., Rajavelu A | 10.1186/s13072-020-00357-5 |
| 32930954 | (1)H, (13)C and (15)N resonance assignment of the YTH domain of YTHDC2 | He F, Endo R, ..., Muto Y | 10.1007/s12104-020-09974-3 |