PF3D7_0309900

Genome location: Pf3D7_03_v3:414,206..419,975(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.23	0.89
Trophozoite	possibly expressed	0.52	0.70
Schizont	not expressed	0.23	0.86
Gametocyte	expressed	0.55	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0309900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.484 | #Insertions: 9

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77332

"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=9.80) with 3CLV (Global RMSD=17.15)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119659

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	12	56	33	76
disruptive	43	140	93	242
missense	38	134	84	210

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	20	117	64	129
disruptive	85	342	195	421
missense	60	286	169	310

PlasmoDB Total SNPs: 192

Non-coding: 77 | Synonymous: 62 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1673 | Molecular Weight (kDa): 203.953

UniProt ID(s): O77332

PDB ID(s): None

Isoelectric Point: 8.21

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095