PF3D7_0310000

Genome location: Pf3D7_03_v3:420,417..421,877(+)

Genome classification: Core

Function and Localization

Product Description: 50S ribosomal protein L9, apicoplast, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	possibly expressed	0.31	0.80
Schizont	not expressed	0.14	0.91
Gametocyte	expressed	0.36	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0310000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.751 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0408100)

Relative Growth Rate: 0.12 ± 0.08
Confidence: 6.56

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NLA7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103651

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	7	2	15
disruptive	4	23	14	39
missense	4	20	14	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	10	7	17
disruptive	12	53	27	63
missense	8	46	24	46

PlasmoDB Total SNPs: 103

Non-coding: 83 | Synonymous: 11 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 197 | Molecular Weight (kDa): 23.374

UniProt ID(s): Q9NLA7

PDB ID(s): None

Isoelectric Point: 10.11

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR009027	Ribosomal protein L9/RNase H1, N-terminal
InterPro	IPR020070	Ribosomal protein L9, N-terminal
PFam	PF01281	Ribosomal protein L9, N-terminal
Superfamily	SSF55658	Ribosomal protein L9/RNase H1, N-terminal

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895