PF3D7_0310200

Genome location: Pf3D7_03_v3:426,151..441,005(+)

Genome classification: Core

Function and Localization

Product Description: phd finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Process	GO:0009410	response to xenobiotic stimulus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	2.54	0.18
Trophozoite	expressed	2.04	0.18
Schizont	expressed	0.79	0.61
Gametocyte	expressed	1.15	0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0310200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.583 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0408300)

Modification: Disrupted | RMgm-1878

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532812

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	36	174	104	234
disruptive	307	680	334	791
missense	136	424	229	541

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	62	367	152	271
disruptive	540	1322	554	1290
missense	236	849	380	723

PlasmoDB Total SNPs: 1112

Non-coding: 119 | Synonymous: 551 | Nonsynonymous: 440 | Stop Codon: 2

Protein Information

Protein Length: 4550 | Molecular Weight (kDa): 534.114

UniProt ID(s): O77336

PDB ID(s): None

Isoelectric Point: 8.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001965	Zinc finger, PHD-type
InterPro	IPR011011	Zinc finger, FYVE/PHD-type
InterPro	IPR019786	Zinc finger, PHD-type, conserved site
PFam	PF13831	N/A
PFam	PF13832
Superfamily	SSF57903	Zinc finger, FYVE/PHD-type
Superfamily	SSF57997

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
29326268	Mapping the malaria parasite druggable genome by using in vitro evolution andchemogenomics.	Cowell AN, Istvan ES, ..., Winzeler EA	10.1126/science.aan4472