About Gene List

PF3D7_0310300

Genome location: Pf3D7_03_v3:441,760..447,410(+)

Genome classification: Core

Function and Localization

Product Description: phosphoglycerate mutase, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: 5.4.2.11 (Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent))

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005634 nucleus
Function GO:0016868 intramolecular transferase activity, phosphotransferases
Function GO:0003729 mRNA binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.95 0.59
Trophozoite expressed 0.94 0.52
Schizont possibly expressed 0.23 0.87
Gametocyte expressed 0.96 0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0310300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.153 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0408400)

  • Relative Growth Rate: 1.07 ± 0.15
  • Confidence: 5.23

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0408400)

Modification: Disrupted | RMgm-1879

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C0H469

"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=0.44) with 3FI8 (Global RMSD=20.76)

BRENDA EC Inhibitors:

EC # Name EC Inhibitors
5.4.2.11 phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) MJE3vanadatePGMI-004AgemcitabinemetavanadatetetrathionateAlizarin Red S2,3-ButanedionediethyldicarbonateSodium metavanadatebenzene hexacarboxylateepigallocatechin gallate...

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533215

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 43 22 62
disruptive 29 88 52 159
missense 19 61 41 130

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 18 77 47 81
disruptive 65 238 132 288
missense 33 163 94 165

PlasmoDB Total SNPs: 252

Non-coding: 174 | Synonymous: 51 | Nonsynonymous: 27 | Stop Codon: 0

Protein Information

Protein Length: 1165 | Molecular Weight (kDa): 138.308

UniProt ID(s): C0H469

PDB ID(s): None

Isoelectric Point: 8.63

Protein Domain Annotations:

Source Family ID Description
InterPro IPR029033 Histidine phosphatase superfamily
PFam N/A N/A
Superfamily SSF53254 Histidine phosphatase superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
27381095 The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. Bunnik EM, Batugedara G, ..., Le Roch KG 10.1186/s13059-016-1014-0