Product Description: phosphoglycerate mutase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.4.2.11 (Phosphoglycerate mutase (2,3-diphosphoglycerate-dependent))
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005737 | cytoplasm |
Component | GO:0005634 | nucleus |
Function | GO:0016868 | intramolecular transferase activity, phosphotransferases |
Function | GO:0003729 | mRNA binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.95 | 0.59 |
Trophozoite | expressed | 0.94 | 0.52 |
Schizont | possibly expressed | 0.23 | 0.87 |
Gametocyte | expressed | 0.96 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0310300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.153 | #Insertions: 5
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0408400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0408400)
Modification: Disrupted | RMgm-1879
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C0H469
"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=0.44) with 3FI8 (Global RMSD=20.76)
BRENDA EC Inhibitors:
EC # | Name | EC Inhibitors |
---|---|---|
5.4.2.11 | phosphoglycerate mutase (2,3-diphosphoglycerate-dependent) | MJE3vanadatePGMI-004AgemcitabinemetavanadatetetrathionateAlizarin Red S2,3-ButanedionediethyldicarbonateSodium metavanadatebenzene hexacarboxylateepigallocatechin gallate... |
No evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 9 | 43 | 22 | 62 |
disruptive | 29 | 88 | 52 | 159 |
missense | 19 | 61 | 41 | 130 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 18 | 77 | 47 | 81 |
disruptive | 65 | 238 | 132 | 288 |
missense | 33 | 163 | 94 | 165 |
PlasmoDB Total SNPs: 252
Non-coding: 174 | Synonymous: 51 | Nonsynonymous: 27 | Stop Codon: 0
Protein Length: 1165 | Molecular Weight (kDa): 138.308
UniProt ID(s): C0H469
PDB ID(s): None
Isoelectric Point: 8.63
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR029033 | Histidine phosphatase superfamily |
PFam | N/A | N/A |
Superfamily | SSF53254 | Histidine phosphatase superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
27381095 | The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum. | Bunnik EM, Batugedara G, ..., Le Roch KG | 10.1186/s13059-016-1014-0 |