PF3D7_0310600 (EIF3K)

Genome location: Pf3D7_03_v3:460,848..462,532(-)

Genome classification: Core

Function and Localization

Product Description: eukaryotic translation initiation factor 3 subunit K, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0310600.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.211 | MFS: -3.232 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0408600)

• Relative Growth Rate: 0.81 ± 0.10
• Confidence: 5.96

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0408600)

Modification: Disrupted | RMgm-1880

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NFE6

"Best" AlphaFill ligand hit: No AlphaFill hits

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103049

Most Similar Human Ortholog: K7ES31

TM-align score: 0.82 | RMSD: 2.29

Seq Identity: 0.20 | Length: 132 / 235

All Human Orthologs (OrthoMCL):

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

Any inclusion in genotype call

PlasmoDB Total SNPs: 104

Non-coding: 74 | Synonymous: 21 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 235 | Molecular Weight (kDa): 28.035

UniProt ID(s): Q9NFE6

PDB ID(s): None

Isoelectric Point: 5.69

Protein Domain Annotations: