Genome location: Pf3D7_03_v3:462,750..464,274(+)
Genome classification: Core
Product Description: trafficking protein particle complex subunit 4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020036 | Maurer's cleft |
| Component | GO:0030008 | TRAPP complex |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.11 | 0.94 |
| Trophozoite | possibly expressed | 0.15 | 0.90 |
| Schizont | not expressed | 0.05 | 0.96 |
| Gametocyte | not expressed | 0.07 | 0.95 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0310700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.133 | MFS: -2.731 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77358
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102399
Most Similar Human Ortholog: Q9Y296
TM-align score: 0.85 | RMSD: 1.48
Seq Identity: 0.38 | Length: 132 / 145
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000196655 | trafficking protein particle complex 4 |
| ENSG00000280495 | trafficking protein particle complex 4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 3 | 3 | 5 |
| disruptive | 0 | 3 | 1 | 8 |
| missense | 0 | 2 | 1 | 8 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 12 | 4 | 6 |
| disruptive | 3 | 11 | 12 | 28 |
| missense | 1 | 7 | 8 | 21 |
PlasmoDB Total SNPs: 73
Non-coding: 67 | Synonymous: 5 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 145 | Molecular Weight (kDa): 17.019
UniProt ID(s): O77358
PDB ID(s): None
Isoelectric Point: 5.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007233 | Trafficking protein particle complex subunit |
| InterPro | IPR011012 | Longin-like domain superfamily |
| PFam | PF04099 | Trafficking protein particle complex subunit |
| Superfamily | SSF64356 | Longin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 31631203 | A network-based approach reveals novel invasion and Maurer's clefts-relatedproteins in Plasmodium falciparum. | Das D, Krishnan SR, Roy A, Bulusu G | 10.1039/c9mo00124g |
| 37091798 | Identifying the genetic causes of phenotypically diagnosed Pakistanimucopolysaccharidoses patients by whole genome sequencing | Gul R, Firasat S, ..., Hansen T | 10.3389/fgene.2023.1128850 |
| 32116085 | TRAPPing a neurological disorder: from yeast to humans | Lipatova Z, Van Bergen N, ..., Segev N | 10.1080/15548627.2020.1736873 |