About Gene List

PF3D7_0311100

Genome location: Pf3D7_03_v3:470,535..473,737(-)

Genome classification: Core

Function and Localization

Product Description: pre-mRNA splicing factor, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.37 0.82
Trophozoite expressed 0.78 0.57
Schizont expressed 0.17 0.89
Gametocyte expressed 0.57 0.68

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0311100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.076 | #Insertions: 1

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0409100)

  • Relative Growth Rate: 0.55 ± 0.27
  • Confidence: 3.98

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0409100)

Modification: Disrupted | RMgm-4210

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77355

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_103077

Most Similar Human Ortholog: M0QXG5

TM-align score: 0.73 | RMSD: 1.62

Seq Identity: 0.39 | Length: 79 / 600

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000133226 serine and arginine repetitive matrix 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 20 32 20 34
disruptive 70 122 59 143
missense 42 76 37 91

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 26 61 31 34
disruptive 99 231 86 181
missense 53 145 54 119

PlasmoDB Total SNPs: 252

Non-coding: 146 | Synonymous: 62 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 600 | Molecular Weight (kDa): 71.663

UniProt ID(s): O77355

PDB ID(s): None

Isoelectric Point: 10.69

Protein Domain Annotations:

Source Family ID Description
InterPro IPR002483 PWI domain
InterPro IPR036483 PWI domain superfamily
PFam PF01480 PWI domain
Superfamily SSF101233 PWI domain superfamily

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108