About Gene List

PF3D7_0311500

Genome location: Pf3D7_03_v3:496,787..498,268(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite not expressed 0.03 0.98
Schizont possibly expressed 0.01 0.99
Gametocyte possibly expressed 0.01 0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0311500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.754 | MFS: 0.908 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_0409500)

  • Relative Growth Rate: 0.97 ± 0.15
  • Confidence: 5.22

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0409500)

Modification: Disrupted | RMgm-1884

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q9NFE5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_127971

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 4 3 5
disruptive 1 3 2 4
missense 1 2 1 4

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 2 9 9 7
disruptive 3 10 10 19
missense 1 8 7 10

PlasmoDB Total SNPs: 118

Non-coding: 110 | Synonymous: 8 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 81 | Molecular Weight (kDa): 9.044

UniProt ID(s): Q9NFE5

PDB ID(s): None

Isoelectric Point: 4.32

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095