PF3D7_0311800

Genome location: Pf3D7_03_v3:506,275..509,040(+)

Genome classification: Core

Function and Localization

Product Description: ATP synthase F0 subunit d-like protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005739	mitochondrion
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.04	0.98
Trophozoite	expressed	0.37	0.77
Schizont	expressed	0.24	0.85
Gametocyte	expressed	0.44	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0311800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.078 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_0409800)

Relative Growth Rate: 0.83 ± 0.13
Confidence: 5.47

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_0409800)

Modification: Disrupted | RMgm-1886

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77349

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139442

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	21	12	44
disruptive	6	26	30	58
missense	5	22	27	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	45	24	45
disruptive	15	75	39	106
missense	9	61	34	71

PlasmoDB Total SNPs: 180

Non-coding: 124 | Synonymous: 33 | Nonsynonymous: 23 | Stop Codon: 0

Protein Information

Protein Length: 609 | Molecular Weight (kDa): 73.524

UniProt ID(s): O77349

PDB ID(s): None

Isoelectric Point: 6.16

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
10448855	The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum.	Bowman S, Lawson D, ..., Barrell BG	10.1038/22964
12368867	Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.	Hall N, Pain A, ..., Barrell BG	10.1038/nature01095
22144892	A systematic screen to discover and analyze apicoplast proteins identifies aconserved and essential protein import factor.	Sheiner L, Demerly JL, ..., Striepen B	10.1371/journal.ppat.1002392
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108
34494883	A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology.	van Esveld SL, Meerstein-Kessel L, ..., Huynen MA	10.1128/mSphere.00614-21