About Gene List

PF3D7_0311900

Genome location: Pf3D7_03_v3:509,155..512,024(-)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.01 0.99
Trophozoite expressed 0.11 0.93
Schizont expressed 0.04 0.97
Gametocyte expressed 0.10 0.94

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0311900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -3.078 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77348

"Best" AlphaFill ligand hit: ACI (6-amino-4-hydroxymethyl-cyclohex-4-ene-1,2,3-triol, Local RMSD=0.04) with 1WPC (Global RMSD=12.62)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215308

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 36 21 28
disruptive 59 71 37 105
missense 30 42 32 86

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 69 20 35
disruptive 83 128 71 145
missense 36 91 57 106

PlasmoDB Total SNPs: 121

Non-coding: 43 | Synonymous: 44 | Nonsynonymous: 34 | Stop Codon: 0

Protein Information

Protein Length: 768 | Molecular Weight (kDa): 92.359

UniProt ID(s): O77348

PDB ID(s): None

Isoelectric Point: 9.69

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095