Product Description: tetratricopeptide repeat protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0072380 | TRC complex |
| Component | GO:0005829 | cytosol |
| Component | GO:0016020 | membrane |
| Function | GO:0060090 | molecular adaptor activity |
| Process | GO:1903646 | positive regulation of chaperone-mediated protein folding |
| Process | GO:0006620 | posttranslational protein targeting to endoplasmic reticulum membrane |
| Process | GO:0030433 | ubiquitin-dependent ERAD pathway |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.06 | 0.97 |
| Trophozoite | not expressed | 0.22 | 0.87 |
| Schizont | possibly expressed | 0.27 | 0.83 |
| Gametocyte | possibly expressed | 0.93 | 0.54 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0312200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.202 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77346
"Best" AlphaFill ligand hit: ADP (adenosine-5'-diphosphate, Local RMSD=5.45) with 3OZX (Global RMSD=14.96)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_105718
Most Similar Human Ortholog: Q07617
TM-align score: 0.37 | RMSD: 7.90
Seq Identity: 0.08 | Length: 496 / 1236
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000104450 | sperm associated antigen 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 53 | 25 | 90 |
| disruptive | 51 | 162 | 101 | 255 |
| missense | 31 | 127 | 92 | 206 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 106 | 50 | 82 |
| disruptive | 88 | 332 | 180 | 327 |
| missense | 44 | 268 | 146 | 252 |
PlasmoDB Total SNPs: 147
Non-coding: 44 | Synonymous: 55 | Nonsynonymous: 47 | Stop Codon: 1
Protein Length: 1236 | Molecular Weight (kDa): 147.956
UniProt ID(s): O77346
PDB ID(s): None
Isoelectric Point: 8.64
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR019734 | Tetratricopeptide repeat |
| PFam | PF13414 | N/A |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |