Product Description: 60S ribosomal protein L26, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0002181 | cytoplasmic translation |
| Process | GO:0042273 | ribosomal large subunit biogenesis |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.85 | 0.29 |
| Trophozoite | expressed | 1.89 | 0.23 |
| Schizont | possibly expressed | 0.48 | 0.72 |
| Gametocyte | not expressed | 1.19 | 0.43 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_0312800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.119 | MFS: -3.099 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: O77364
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100790
Most Similar Human Ortholog: P61254
TM-align score: 0.98 | RMSD: 0.58
Seq Identity: 0.62 | Length: 126 / 126
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000037241 | ribosomal protein L26 like 1 |
| ENSG00000161970 | ribosomal protein L26 |
| ENSG00000263809 | novel protein |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 7 | 3 | 5 |
| disruptive | 0 | 5 | 3 | 0 |
| missense | 0 | 5 | 3 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 1 | 12 |
| disruptive | 0 | 13 | 6 | 28 |
| missense | 0 | 11 | 1 | 12 |
PlasmoDB Total SNPs: 151
Non-coding: 150 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 126 | Molecular Weight (kDa): 14.813
UniProt ID(s): O77364
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 11.75
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005756 | Ribosomal protein L26/L24, eukaryotic/archaeal |
| InterPro | IPR005824 | KOW |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR041988 | Ribosomal protein L26/L24, KOW domain |
| PFam | PF00467 | KOW |
| PFam | PF16906 | Ribosomal protein L26/L24, eukaryotic/archaeal |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 10448855 | The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. | Bowman S, Lawson D, ..., Barrell BG | 10.1038/22964 |
| 12368867 | Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. | Hall N, Pain A, ..., Barrell BG | 10.1038/nature01095 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |