About Gene List

PF3D7_0312900

Genome location: Pf3D7_03_v3:535,938..537,274(+)

Genome classification: Core

Function and Localization

Product Description: hypothetical protein

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.11 0.94
Trophozoite expressed 0.07 0.96
Schizont possibly expressed 0.02 0.99
Gametocyte expressed 0.06 0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_0312900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.989 | MFS: -1.991 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: O77342

"Best" AlphaFill ligand hit: UPG (uridine-5'-diphosphate-glucose, Local RMSD=2.08) with 2VKD (Global RMSD=23.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532979

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 11 3 12
disruptive 14 41 23 70
missense 6 27 14 56

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 23 10 16
disruptive 26 94 59 90
missense 15 62 43 47

PlasmoDB Total SNPs: 128

Non-coding: 58 | Synonymous: 40 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 273 | Molecular Weight (kDa): 32.602

UniProt ID(s): O77342

PDB ID(s): None

Isoelectric Point: 9.52

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
10448855 The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum. Bowman S, Lawson D, ..., Barrell BG 10.1038/22964
12368867 Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13. Hall N, Pain A, ..., Barrell BG 10.1038/nature01095